This Handbook constitutes a global resource for the fast-growing interdisciplinary research and policy communities that have taken on the challenge of driving innovation towards socially desirable outcomes. The collection brings together well-known authors from the USA, Europe, Asia and South Africa, developing conceptual and regional perspectives on responsible innovation including issues of governance, economics and ethics. The authors explore the prospects for the further implementation of responsible innovation in emerging technological practices in sectors from agriculture and health-care to nanotechnology, robotics and artificial intelligence. The collection emphasises the socio-economic and normative dimensions of innovation, including issues of social risk and sustainability.